Chromosomal instability in cancer consists of dynamic changes to the number and structure
of chromosomes 1 , 2 . The resulting diversity in somatic copy number alterations (SCNAs) …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity 1 . The interplay of these biological processes and their respective …

Colorectal malignancies are a leading cause of cancer-related death 1 and have undergone
extensive genomic study 2 , 3 . However, DNA mutations alone do not fully explain …

Most cancer genomic data are generated from bulk samples composed of mixtures of
cancer subpopulations, as well as normal cells. Subclonal reconstruction methods based on …

Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer
therapy today. However, evolving resistance to one drug may come at a cost of decreased …

The evolution of pediatric solid tumors is poorly understood. There is conflicting evidence of
intra-tumor genetic homogeneity vs. heterogeneity (ITGH) in a small number of studies in …

Both normal tissue development and cancer growth are driven by a branching process of
cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. …

Circulating tumour DNA (ctDNA) allows tracking of the evolution of human cancers at high
resolution, overcoming many limitations of tissue biopsies. However, exploiting ctDNA to …

Objective Epidermal growth factor receptor (EGFR) inhibition may be effective in biomarker-selected
populations of advanced gastro-oesophageal adenocarcinoma (aGEA) patients. …

This study advances the understanding of therapy-induced dormancy with potential clinical
implications for breast cancer. Estrogen receptor-positive breast cancer cells adapt to …