User profiles for George Georgiou

George Georgiou

- Verified email at che.utexas.edu - Cited by 43452

George Georgiou

- Verified email at bham.ac.uk - Cited by 1113

High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire

…, CG Willson, AD Ellington, G Georgiou - Nature …, 2013 - nature.com
Each B-cell receptor consists of a pair of heavy and light chains. High-throughput sequencing
can identify large numbers of heavy- and light-chain variable regions (V H and V L ) in a …

Virus-based toolkit for the directed synthesis of magnetic and semiconducting nanowires

…, ST Kottmann, RY Sweeney, A Hayhurst, G Georgiou… - Science, 2004 - science.org
We report a virus-based scaffold for the synthesis of single-crystal ZnS, CdS, and freestanding
chemically ordered CoPt and FePt nanowires, with the means of modifying substrate …

[HTML][HTML] The promise and challenge of high-throughput sequencing of the antibody repertoire

G Georgiou, GC Ippolito, J Beausang, CE Busse… - Nature …, 2014 - nature.com
Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid
organs using high-throughput DNA sequencing technologies have been advancing at an …

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

…, C Lamb, Y Tanno, M Cieslik, E Stone, G Georgiou… - Nature, 2019 - nature.com
Cancer immunotherapy restores or enhances the effector function of CD8 + T cells in the
tumour microenvironment 1 , 2 . CD8 + T cells activated by cancer immunotherapy clear …

Isolation of engineered, full-length antibodies from libraries expressed in Escherichia coli

…, T Van Blarcom, R Mabry, BL Iverson, G Georgiou - Nature …, 2007 - nature.com
We describe facile isolation of full-length IgG antibodies from combinatorial libraries expressed
in E. coli. Full-length heavy and light chains are secreted into the periplasm, where they …

The substance of accounting for public‐private partnerships

D Heald, G Georgiou - Financial Accountability & Management, 2011 - Wiley Online Library
This article evaluates Public‐Private Partnerships (PPP) accounting practice and the related
financial accounting and reporting requirements. Governments across the world are …

Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm

…, F Åslund, J Beckwith, G Georgiou - Proceedings of the …, 1999 - National Acad Sciences
Under physiological conditions, the Escherichia coli cytoplasm is maintained in a reduced
state that strongly disfavors the formation of stable disulfide bonds in proteins. However, …

Cysteine depletion induces pancreatic tumor ferroptosis in mice

…, C Lamb, T Liu, W Gu, ES Seeley, E Stone, G Georgiou… - Science, 2020 - science.org
Ferroptosis is a form of cell death that results from the catastrophic accumulation of lipid
reactive oxygen species (ROS). Oncogenic signaling elevates lipid ROS production in many …

[HTML][HTML] Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

…, IA Wilson, JP Moore, AB Ward, G Georgiou… - Nature, 2014 - nature.com
Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …

Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines

G Georgiou, C Stathopoulos, PS Daugherty… - Nature …, 1997 - nature.com
In recent years there has been considerable progress towards the development of
expression systems for the display of heterologous polypeptides and, to a lesser extent, …