Depressive disorders account for a large and increasing global burden of disease. Although
the condition of many patients improves with medication, only a minority experience full …

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans
has been accumulating over the last decade, in particular a large number of loci derived from …

Linear mixed models (LMMs) are widely used in genome-wide association studies (GWASs)
to account for population structure and relatedness, for both continuous and binary traits. …

Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify
common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL…

Recombination, together with mutation, gives rise to genetic variation in populations. Here we
leverage the recent mixture of people of African and European ancestry in the Americas to …

US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …

Meta-analyses of association results for blood pressure using exome-centric single-variant
and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, …

Most genome-wide association and fine-mapping studies to date have been conducted in
individuals of European descent, and genetic studies of populations of Hispanic/Latino and …

Context TheHTTLPR, a functional polymorphism of the serotonin transporter gene solute
carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), promoter, affects …

Background The discovery of disease-associated loci through genome-wide association
studies (GWAS) is the leading genetic approach to the identification of novel biological …