• Environmental stress may contribute to the clinical morbidity of established cases of
schizophrenia treated with optimal neuroleptic drugs. A family-based approach that aimed to …

The National Institute of Mental Health initiated the Clinical Antipsychotic Trials of Intervention
Effectiveness (CATIE) program to evaluate the effectiveness of antipsychotic drugs in …

Method Cigarette smoking was measured in all patients hospitalized at a state hospital (N=
360) and compared in relation to gender and diagnosis (schizophrenic versus …

Background: Previous studies have examined dose reduction and family treatment in
schizophrenia, but none has examined their interaction. This study assessed the impact of dose …

Polydipsia among chronic psychiatric patients is poorly understood and underdiagnosed. It
may have three stages: simple polydipsia, polydipsia with water intoxication, and physical …

OBJECTIVE: Limited randomized, controlled trial data exist on possible differences between
atypical antipsychotics in efficacy, overall tolerability, and important indices of health status. …

Background: Although agitation associated with psychosis is a common presentation in the
psychiatric emergency service, there is no consensus concerning the best treatment. …

The authors are affiliated with the department of psychiatry and the behavioral sciences at the
Keck School of Medicine of the University of Southern California, 2020 Zonal Avenue, Los …

OBJECTIVE: This study explored the relative efficacy of three different doses of clozapine.
METHOD: Fifty patients who met Kane et al.’s criteria for treatment-refractory schizophrenia or …

Clozapine, which has had limited clinical testing in the USA, was evaluated in 12 chronic
schizophrenic patients with tardive dyskinesia. Its antipsychotic activity was again …