Background Acute exacerbations adversely affect patients with chronic obstructive pulmonary
disease (COPD). Macrolide antibiotics benefit patients with a variety of inflammatory …

Significant heterogeneity of clinical presentation and disease progression exists within
chronic obstructive pulmonary disease (COPD). Although FEV 1 inadequately describes this …

Despite substantial progress in reducing the global impact of many non-communicable
diseases, including heart disease and cancer, morbidity and mortality due to chronic respiratory …

We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung
disease, by profiling 312,928 cells from 32 IPF, 28 smoker and nonsmoker controls, and 18 …

Background Cigarette smoking is associated with emphysema and radiographic interstitial
lung abnormalities. The degree to which interstitial lung abnormalities are associated with …

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity,
mortality, and resource use worldwide. The goal of this Official American Thoracic Society (…

Background Exacerbations of chronic obstructive pulmonary disease (COPD) are associated
with accelerated loss of lung function and death. Identification of patients at risk for these …

The pathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear, but
involves loss of alveolar surface area (emphysema) and airway inflammation (bronchitis) as …

Purpose To test the hypothesis—given the increasing emphasis on quantitative computed
tomographic (CT) phenotypes of chronic obstructive pulmonary disease (COPD)—that a …

Importance Airflow obstruction on spirometry is universally used to define chronic obstructive
pulmonary disease (COPD), and current or former smokers without airflow obstruction may …