User profiles for George Sflomos
George Sflomos, M.Sc., Ph.D.Swiss Federal Institute of Technology in Lausanne, Verified email at epfl.ch Cited by 1184 |
Patient-derived xenograft (PDX) models in basic and translational breast cancer research
Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly
supplanting long-established traditional cell lines as preferred models for conducting basic and …
supplanting long-established traditional cell lines as preferred models for conducting basic and …
[HTML][HTML] Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor
…, M Fiche, P Bucher, G Ambrosini, G Sflomos… - Nature …, 2022 - nature.com
Estrogen and progesterone receptor (ER, PR) signaling control breast development and
impinge on breast carcinogenesis. ER is an established driver of ER + disease but the role of …
impinge on breast carcinogenesis. ER is an established driver of ER + disease but the role of …
Progesterone/RANKL is a major regulatory axis in the human breast
T Tanos, G Sflomos, PC Echeverria… - Science translational …, 2013 - science.org
Estrogens and progesterones are major drivers of breast development but also promote
carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their …
carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their …
[PDF][PDF] A preclinical model for ERα-positive breast cancer points to the epithelial microenvironment as determinant of luminal phenotype and hormone response
Seventy-five percent of breast cancers are estrogen receptor α positive (ER + ). Research
on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require …
on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require …
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity
Functional studies giving insight into the biology of circulating tumor cells ( CTC s) remain
scarce due to the low frequency of CTC s and lack of appropriate models. Here, we describe …
scarce due to the low frequency of CTC s and lack of appropriate models. Here, we describe …
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1
Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast
cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other …
cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other …
[HTML][HTML] The challenges of modeling hormone receptor-positive breast cancer in mice
BC Özdemir, G Sflomos… - Endocrine-related cancer, 2018 - erc.bioscientifica.com
Estrogen receptor-positive (ER+) tumors account for 70–80% of all breast cancer (BC) cases
and are characterized by estrogen dependency for their growth. Endocrine therapies using …
and are characterized by estrogen dependency for their growth. Endocrine therapies using …
[HTML][HTML] Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
Oestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent
activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland …
activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland …
Intraductal patient‐derived xenografts of estrogen receptor α‐positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human …
Estrogen receptor α‐positive (ER‐positive) or ‘luminal’ breast cancers were notoriously difficult
to establish as patient‐derived xenografts (PDXs). We and others recently demonstrated …
to establish as patient‐derived xenografts (PDXs). We and others recently demonstrated …
[HTML][HTML] Atlas of lobular breast cancer models: challenges and strategic directions
Simple Summary Invasive lobular breast cancer (ILC) is the second most common
histological subtype of invasive breast cancer, which is noted to have a unique microscopic …
histological subtype of invasive breast cancer, which is noted to have a unique microscopic …