Treatment with an anti-CK2 synthetic peptide improves clinical response in COVID-19 patients with pneumonia. A randomized and controlled clinical trial
…, A González, R Reyes, L Torres, J Pérez… - ACS pharmacology & …, 2020 - ACS Publications
The instrumental role of CK2 in the SARS-CoV-2 infection has pointed out this protein kinase
as promising therapeutic target in COVID-19. Anti-SARS-CoV-2 activity has been reported …
as promising therapeutic target in COVID-19. Anti-SARS-CoV-2 activity has been reported …
[HTML][HTML] Gene expression profiling unveils the temporal dynamics of CIGB-300-regulated transcriptome in AML cell lines
…, AC Ramón, M Rosales, GV Pérez… - BMC genomics, 2023 - Springer
Background Protein kinase CK2 activity is implicated in the pathogenesis of various
hematological malignancies like Acute Myeloid Leukemia (AML) that remains challenging …
hematological malignancies like Acute Myeloid Leukemia (AML) that remains challenging …
[HTML][HTML] Postmortem findings in patient with Guillain-Barré syndrome and Zika virus infection
…, S Reagan-Steiner, GV Perez… - Emerging infectious …, 2018 - ncbi.nlm.nih.gov
Postmortem examination results of a patient with Guillain-Barré syndrome and confirmed
Zika virus infection revealed demyelination of the sciatic and cranial IV nerves, providing …
Zika virus infection revealed demyelination of the sciatic and cranial IV nerves, providing …
[HTML][HTML] Targeting of protein kinase CK2 in acute myeloid leukemia cells using the clinical-grade synthetic-peptide CIGB-300
Protein kinase CK2 has emerged as an attractive therapeutic target in acute myeloid
leukemia (AML), an advent that becomes particularly relevant since the treatment of this …
leukemia (AML), an advent that becomes particularly relevant since the treatment of this …
[HTML][HTML] CIGB-300 anticancer peptide differentially interacts with CK2 subunits and regulates specific signaling mediators in a highly sensitive large cell lung …
GV Pérez, M Rosales, AC Ramón, A Rodríguez-Ulloa… - Biomedicines, 2022 - mdpi.com
Large cell lung carcinoma (LCLC) is one form of NSCLC that spreads more aggressively than
some other forms, and it represents an unmet medical need. Here, we investigated for the …
some other forms, and it represents an unmet medical need. Here, we investigated for the …
[HTML][HTML] Phosphoproteomic landscape of AML cells treated with the ATP-competitive CK2 inhibitor CX-4945
Casein kinase 2 (CK2) regulates a plethora of proteins with pivotal roles in solid and
hematological neoplasia. Particularly, in acute myeloid leukemia (AML) CK2 has been pointed as …
hematological neoplasia. Particularly, in acute myeloid leukemia (AML) CK2 has been pointed as …
[HTML][HTML] Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection
Coronaviruses constitute a global threat to the human population; therefore, effective pan-coronavirus
antiviral drugs are required to tackle future re-emerging virus outbreaks. Protein …
antiviral drugs are required to tackle future re-emerging virus outbreaks. Protein …
[HTML][HTML] CIGB-300-Regulated proteome reveals common and tailored response patterns of AML Cells to CK2 inhibition
M Rosales, A Rodríguez-Ulloa, GV Pérez… - Frontiers in molecular …, 2022 - frontiersin.org
Protein kinase CK2 is a highly pleiotropic and ubiquitously expressed Ser/Thr kinase with
instrumental roles in normal and pathological states, including neoplastic phenotype in solid …
instrumental roles in normal and pathological states, including neoplastic phenotype in solid …
[PDF][PDF] Ética profesional y su concepción responsable para la investigación científica
NC Sotomayor, GA Pérez, LC Saavedra, RC Pérez… - Rev …, 2018 - academia.edu
En la actualidad, la ética profesional constituye el erario conductual en la humanidad, donde
no siempre se expresa de forma consciente para su contribución a las investigaciones …
no siempre se expresa de forma consciente para su contribución a las investigaciones …
Microplásticos en la zona de marea alta y supralitoral de una playa arenosa del litoral costero del Perú
…, DM Angoma, J Ortega, GA Pérez, LGC Perez - The …, 2019 - dialnet.unirioja.es
En los últimos años, el plástico se ha convertido en un material de uso común empleado en
distintas actividades antropogénicas. Los microplásticos (MP) provienen de la …
distintas actividades antropogénicas. Los microplásticos (MP) provienen de la …