To define alterations of neuronal connectivity that occur during motor neuron degeneration,
we characterized the function and structure of spinal circuitry in spinal muscular atrophy (…

Mutations in FUS cause amyotrophic lateral sclerosis (ALS), including some of the most
aggressive, juvenile-onset forms of the disease. FUS loss-of-function and toxic gain-of-function …

Spinal muscular atrophy (SMA) is a motor neuron disease caused by deficiency of the
ubiquitous survival motor neuron (SMN) protein. To define the mechanisms of selective neuronal …

Animals generate movement by engaging spinal circuits that direct precise sequences of
muscle contraction, but the identity and organizational logic of local interneurons that lie at the …

The neurodegenerative disease spinal muscular atrophy (SMA) is caused by deficiency in
the survival motor neuron (SMN) protein. Currently approved SMA treatments aim to restore …

Mammalian spinal motoneurons are considered to be output elements of the spinal cord that
generate exclusively cholinergic actions on Renshaw cells, their intraspinal synaptic targets…

Movement is an essential behavior requiring the assembly and refinement of spinal motor
circuits. However, the mechanisms responsible for circuit refinement and synapse …

Gene replacement and pre-mRNA splicing modifier therapies represent breakthrough gene
targeting treatments for the neuromuscular disease spinal muscular atrophy (SMA), but …

Behavioral deficits in neurodegenerative diseases are often attributed to the selective dysfunction
of vulnerable neurons via cell-autonomous mechanisms. Although vulnerable neurons …

Proprioceptive feedback mainly derives from groups Ia and II muscle spindle (MS) afferents
and group Ib Golgi tendon organ (GTO) afferents, but the molecular correlates of these three …