The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

10.7554/eLife.08527.001 An integrated account of the molecular changes occurring during
the process of cellular aging is crucial towards understanding the underlying mechanisms. …

Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical
function. However, the underlying molecular processes and how (lack of) physical activity is …

The ability to perceive and respond to harmful conditions is crucial for the survival of any
organism. The transcription factor DAF-16/FOXO is central to these responses, relaying distress …

Slowing down translation in either the cytosol or the mitochondria is a conserved longevity
mechanism. Here, we found a non-interventional natural correlation of mitochondrial and …

Reversing or slowing the aging process brings great promise to treat or prevent age‐related
disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics …

Recently, efforts have been made to characterize the hallmarks that accompany and contribute
to the phenomenon of aging, as most relevant for humans 1. Remarkably, studying the …

Since the identification and definition of the hallmarks of aging, these aspects of molecular
and cellular decline have been most often described as isolated or distinct mechanisms. …

Life expectancy has increased substantially over the last 150 years. Yet this means that now
most people also spend a greater length of time suffering from various age-associated …

Background Over 80% of women with X-linked adrenoleukodystrophy (ALD) develop spinal
cord disease in adulthood for which treatment is supportive only. For future clinical trials …