Innate immunity is associated with Alzheimer’s disease 1 , but the influence of immune
activation on the production of amyloid-β is unknown 2 , 3 . Here we identify interferon-induced …

Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ) plaques,
intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the brain. It …

The hemizygous R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2),
a microglia-specific gene in the brain, increases risk for late-onset Alzheimer’s disease (AD)…

Photodynamic therapy (PDT) of non-melanoma skin cancers currently carries failure rates of
10–40%. The optimal irradiation protocol is as yet unclear. Previous studies showed …

Alzheimer’s disease (AD) is marked by the presence of amyloid beta (Aβ) plaques, neurofibrillary
tangles (NFT), neuronal death and synaptic loss, and inflammation in the brain. AD …

Amyloid-beta (Aβ) deposition occurs in the early stages of Alzheimer’s disease (AD), but the
early detection of Aβ is a persistent challenge. Herein, we engineered a near-infrared …

Hypoxic-ischemic injury has been linked with increased risk for developing Alzheimer’s
disease (AD). The underlying mechanism of this association is poorly understood. Here, we …

Compelling evidence links amyloid beta (Aβ) peptide accumulation in the brains of Alzheimer's
disease (AD) patients with the emergence of learning and memory deficits, yet a clear …

The emergence of PET probes for amyloid plaques and neurofibrillary tangles, hallmarks of
Alzheimer disease (AD), enables monitoring of pathology in AD mouse models. However, …

Described as the “proteasome of the membrane” or the “scissors in the membrane,” γ-secretase
has notoriously complicated biology, and even after decades of research, the full extent …