Several forms of human sarcoma, lymphoma, and leukemia are characterized by somatically
acquired chromosome translocations that result in fusion genes that encode chimeric …

Alveolar rhabdomyosarcoma is an aggressive pediatric cancer of striated muscle
characterized in 60% of cases by at(2;13)(q35;q14). This results in the fusion of PAX3, a …

Breast cancer cell lines provide a useful starting point for the discovery and functional analysis
of genes involved in breast cancer. Here, we studied 38 established breast cancer cell …

Background A number of clinico-pathological criteria and molecular profiles have been
used to stratify patients into high- and low-risk groups. Currently, there are still no effective …

Mitochondrial DNA (mtDNA) mutations and polymorphisms contribute to many complex
diseases, including cancer. Using a unique mouse model that contains nDNA from one mouse …

Background Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases,
which has been studied extensively and is approved for myelodysplastic syndrome …

Context Adrenocortical carcinomas (ACC) are a rare tumor type with a poor five-year survival
rate and limited treatment options. Objective Understanding of the molecular pathogenesis …

High-content cell imaging based on fluorescent protein reporters has recently been used to
track the transcriptional activities of multiple genes under different external stimuli for …

Eosinophils have been widely investigated in asthma and allergic diseases. More recently,
new insights into the biology of these cells has illustrated eosinophils contribute to …

Genomic technologies, such as array comparative genomic hybridization (aCGH),
increasingly offer definitive gene dosage profiles in clinical samples. Historically, copy number …