User profiles for Gerben Ferwerda

Gerben Ferwerda

MD PhD
Verified email at radboudumc.nl
Cited by 9111

Syk kinase is required for collaborative cytokine production induced through Dectin‐1 and Toll‐like receptors

KM Dennehy, G Ferwerda… - European journal of …, 2008 - Wiley Online Library
Recognition of microbial components by germ‐line encoded pattern recognition receptors (PRR)
initiates immune responses to infectious agents. We and others have proposed that …

[HTML][HTML] Human dectin-1 deficiency and mucocutaneous fungal infections

B Ferwerda, G Ferwerda, TS Plantinga… - … England Journal of …, 2009 - Mass Medical Soc
<p id="p001">Mucocutaneous fungal infections are typically found in patients who have no
known immune defects. We describe a family in which four women who were affected by …

Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

…, FL van de Veerdonk, G Ferwerda… - Blood, The Journal …, 2009 - ashpublications.org
The processing of pro-interleukin-1β depends on activation of caspase-1. Controversy has
arisen whether Toll-like receptor (TLR) ligands alone can activate caspase-1 for release of …

[HTML][HTML] Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

…, S Bates, C Collins, G Ferwerda… - The Journal of …, 2006 - Am Soc Clin Investig
The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer
layer of proteins glycosylated with N-or O-linked mannosyl residues and an inner skeletal …

[HTML][HTML] NOD2 and Toll-Like Receptors Are Nonredundant Recognition Systems of Mycobacterium tuberculosis

G Ferwerda, SE Girardin, BJ Kullberg… - PLoS …, 2005 - journals.plos.org
Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide.
Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of both …

Dectin‐1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages

G Ferwerda, F Meyer‐Wentrup, BJ Kullberg… - Cellular …, 2008 - Wiley Online Library
The β‐glucan receptor dectin‐1 and Toll‐like receptors TLR2 and TLR4 are the main receptors
for recognition of Candida albicans by the innate immune system. It has been reported …

[HTML][HTML] Fc-mediated antibody effector functions during respiratory syncytial virus infection and disease

EA Van Erp, W Luytjes, G Ferwerda… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract
infections and hospitalization in infants under 1 year of age and there is currently no market-approved …

Immune Recognition of Candida albicans β-glucan by Dectin-1

…, MG Netea, CA Munro, G Ferwerda… - The Journal of …, 2007 - academic.oup.com
β(1,3)-glucans represent 40% of the cell wall of the yeast Candida albicans. The dectin-1
lectin-like receptor has shown to recognize fungal β(1,3)-glucans and induce innate immune …

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1β and IL-6 production through a caspase 1-dependent mechanism

MG Netea, T Azam, G Ferwerda… - Proceedings of the …, 2005 - National Acad Sciences
The activation of innate immunity requires the amplification of signals induced by pattern-recognition
receptors for bacterial products. We have investigated the role of the newly …

How uterine microbiota might be responsible for a receptive, fertile endometrium

M Benner, G Ferwerda, I Joosten… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Fertility depends on a receptive state of the endometrium, influenced by
hormonal and anatomical adaptations, as well as the immune system. Local and systemic …