Neural consequences of enviromental enrichment

H Van Praag, G Kempermann, FH Gage - Nature Reviews …, 2000 - nature.com
Neuronal plasticity is a central theme of modern neurobiology, from cellular and molecular
mechanisms of synapse formation in Drosophila to behavioural recovery from strokes in …

Milestones of neuronal development in the adult hippocampus

G Kempermann, S Jessberger, B Steiner… - Trends in …, 2004 - cell.com
Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus
and results in new granule cell neurons. We propose a model of the development that takes …

More hippocampal neurons in adult mice living in an enriched environment

G Kempermann, HG Kuhn, FH Gage - Nature, 1997 - nature.com
Neurogenesis occurs in the dentate gyrus of the hippocampus throughout the life of a rodent
1–4 , but the function of these new neurons and the mechanisms that regulate their birth are …

[PDF][PDF] Human adult neurogenesis: evidence and remaining questions

G Kempermann, FH Gage, L Aigner, H Song, MA Curtis… - Cell stem cell, 2018 - cell.com
Renewed discussion about whether or not adult neurogenesis exists in the human
hippocampus, and the nature and strength of the supporting evidence, has been reignited by two …

Why new neurons? Possible functions for adult hippocampal neurogenesis

G Kempermann - Journal of neuroscience, 2002 - Soc Neuroscience
The dentate gyrus of the adult hippocampal formation generates neurons throughout life. To
date, it remains unclear why. What are the new neurons used for? How can an existing …

Emergence of individuality in genetically identical mice

…, N Sachser, U Lindenberger, G Kempermann - Science, 2013 - science.org
Brain plasticity as a neurobiological reflection of individuality is difficult to capture in animal
models. Inspired by behavioral-genetic investigations of human monozygotic twins reared …

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

H Van Praag, G Kempermann, FH Gage - Nature neuroscience, 1999 - nature.com
Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult
rodents. Environmental enrichment, however, typically consists of many components, such …

Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance

…, M Ewers, N Franzmeier, G Kempermann… - Alzheimer's & …, 2020 - Wiley Online Library
Several concepts, which in the aggregate get might be used to account for “resilience”
against age‐ and disease‐related changes, have been the subject of much research. These …

Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment

G Kempermann, D Gast, FH Gage - Annals of neurology, 2002 - Wiley Online Library
Neurons are continually born from endogenous stem cells and added to the dentate gyrus
throughout life, but adult hippocampal neurogenesis declines precipitously with age. Short‐…

Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

…, CM Cooper‐Kuhn, G Kempermann… - European journal of …, 2003 - Wiley Online Library
Exposure to an enriched environment and physical activity, such as voluntary running, increases
neurogenesis of granule cells in the dentate gyrus of adult mice. These stimuli are also …