User profiles for Gerd Pfeifer
 | Gerd P. PfeiferVan Andel Research Institute Verified email at vai.org Cited by 43495 |
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
It is estimated that cigarette smoking kills over 1 000 000 people each year by causing lung
cancer as well as many other neoplasmas. p53 mutations are frequent in tobacco-related …
cancer as well as many other neoplasmas. p53 mutations are frequent in tobacco-related …
Mutations induced by ultraviolet light
The different ultraviolet (UV) wavelength components, UVA (320–400nm), UVB (280–320nm),
and UVC (200–280nm), have distinct mutagenic properties. A hallmark of UVC and UVB …
and UVC (200–280nm), have distinct mutagenic properties. A hallmark of UVC and UVB …
UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer
GP Pfeifer, A Besaratinia - Photochemical & photobiological sciences, 2012 - pubs.rsc.org
Ultraviolet (UV) irradiation from the sun has been epidemiologically and mechanistically
linked to skin cancer, a spectrum of diseases of rising incidence in many human populations. …
linked to skin cancer, a spectrum of diseases of rising incidence in many human populations. …
Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53
MF Denissenko, A Pao, M Tang, GP Pfeifer - Science, 1996 - science.org
Cigarette smoke carcinogens such as benzo[a]pyrene are implicated in the development of
lung cancer. The distribution of benzo[a]pyrene diol epoxide (BPDE) adducts along exons of …
lung cancer. The distribution of benzo[a]pyrene diol epoxide (BPDE) adducts along exons of …
Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21. 3
…, C Li, JH Yoon, PL Chin, S Bates, GP Pfeifer - Nature …, 2000 - nature.com
Allelic loss at the short arm of chromosome 3 is one of the most common and earliest events
in the pathogenesis of lung cancer, and is observed in more than 90% of small-cell lung …
in the pathogenesis of lung cancer, and is observed in more than 90% of small-cell lung …
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
Sperm and eggs carry distinctive epigenetic modifications that are adjusted by
reprogramming after fertilization 1 . The paternal genome in a zygote undergoes active DNA …
reprogramming after fertilization 1 . The paternal genome in a zygote undergoes active DNA …
Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine
Genome-wide erasure of DNA cytosine-5 methylation has been reported to occur along the
paternal pronucleus in fertilized oocytes in an apparently replication-independent manner, …
paternal pronucleus in fertilized oocytes in an apparently replication-independent manner, …
Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine
SG Jin, S Kadam, GP Pfeifer - Nucleic acids research, 2010 - academic.oup.com
DNA cytosine-5 methylation is a well-studied epigenetic pathway implicated in gene
expression control and disease pathogenesis. Different technologies have been developed to …
expression control and disease pathogenesis. Different technologies have been developed to …
Patterns of p53 G→ T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke
P Hainaut, GP Pfeifer - Carcinogenesis, 2001 - academic.oup.com
It is unquestionable that the major cause of lung cancer is cigarette smoking. p53 mutations
are common in lung cancers from smokers but less common in non-smokers. A large fraction …
are common in lung cancers from smokers but less common in non-smokers. A large fraction …
[HTML][HTML] Aging and DNA methylation
M Jung, GP Pfeifer - BMC biology, 2015 - Springer
In this Opinion article, we summarize how changes in DNA methylation occur during aging
in mammals and discuss examples of how such events may contribute to the aging process. …
in mammals and discuss examples of how such events may contribute to the aging process. …