Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest.
It is not established what developmental processes neuroblastoma cancer cells represent…

In this letter, we re-analyze human fetal adrenal data generated by Dong et al. to demonstrate
the pitfalls of relying on mouse marker genes to annotate human data. We show that …

Tumor cells may share some patterns of gene expression with their cell of origin, providing
clues into the differentiation state and origin of cancer. Here, we study the differentiation state …

The adrenal glands synthesize and release essential steroid hormones such as cortisol and
aldosterone, but many aspects of human adrenal gland development are not well …

A fundamental step of tumour single cell mRNA analysis is separating cancer and non-cancer
cells. We show that the common approach to separation, using shifts in average …

Background Most animals employ telomerase, which consists of a catalytic subunit known
as the telomerase reverse transcriptase (TERT) and an RNA template, to maintain telomere …

Background As normal cells transform into cancers, their cell state changes, which may
drive cancer cells into a stem-like or more primordial, foetal, or embryonic cell state. The …

The adrenal glands synthesize and release essential steroid hormones such as cortisol and
aldosterone, but the mechanisms underlying human adrenal gland development are not …

Cancer cells arise from normal cells, and may retain transcriptional patterns present in the
cell of origin. Recent advances in single-cell transcriptomics have allowed us to profile both …

Neuroblastoma is an embryonal childhood cancer that arises from aberrant development of
the neural crest, mostly within the fetal adrenal medulla. It is not established what …