The understanding of brain computations requires methods that read out neural activity on
different spatial and temporal scales. Following signal propagation and integration across a …

Structure determination of proteins and other macromolecules has historically required the
growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding …

Microglia are the main immune cells of the brain and contribute to common brain diseases.
However, it is unclear how microglia influence neuronal activity and survival in the injured …

The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host
protein degradation, is a promising target to develop new treatments against sleeping …

Dendritic spines have been proposed to transform synaptic signals through chemical and
electrical compartmentalization. However, the quantitative contribution of spine morphology to …

Cortical synapses have structural, molecular and functional heterogeneity; our knowledge
regarding the relationship between their ultrastructural and functional parameters is still …

Extracting neuronal spiking activity from large-scale two-photon recordings remains challenging,
especially in mammals in vivo, where large noises often contaminate the signals. We …

We describe a method to measure ultrafast protein structural changes using time-resolved
wide-angle X-ray scattering at an X-ray free-electron laser. We demonstrated this approach …

DOI: 10.1002/adma. 201500218 channel to the hippocampus to stimulate targeted populations
of neurons with no degradation in transistor performance. In addition, neurons located as …

X-ray free electron laser (X-FEL)-based serial femtosecond crystallography is an emerging
method with potential to rapidly advance the challenging field of membrane protein structural …