Samples of proximal and distal tubular fluid were collected from rats maintained on a control,
a low-K, or a high-K, low-Na diet. All animals received inulin-C 14 . Plasma (P) and tubular …

Glucagon-like peptide-1 (GLP-1) is a gut incretin hormone considered a promising therapeutic
agent for type 2 diabetes because it stimulates beta cell proliferation and insulin secretion …

Na+-glucose cotransporter 1 (SGLT1)-mediated glucose uptake leads to activation of Na+-H+
exchanger 3 (NHE3) in the intestine by a process that is not dependent on glucose …

METHODS Male albino rats weighing 300-450 g, anesthetized by intraperitoneal injection
of pentobarbital(30-40 mg/kg body wt) were used. One group of animals had free access to …

The gut incretin hormone glucagon-like peptide 1 (GLP-1) is released in response to ingested
nutrients and enhances insulin secretion. In addition to its insulinotropic properties, GLP-1 …

Type II Bartter's syndrome is a hereditary hypokalemic renal salt-wasting disorder caused by
mutations in the ROMK channel (Kir1.1; Kcnj1), mediating potassium recycling in the thick …

Glucagon like peptide-1 (GLP-1) is an incretin hormone constantly secreted from the intestine
at low basal levels in the fasted state; plasma concentrations rise rapidly after nutrient …

In the microvillar microdomain of the kidney brush border, sodium hydrogen exchanger type
3 (NHE3) exists in physical complexes with the serine protease dipeptidyl peptidase IV (…

Background SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity,
regardless of the presence or absence of diabetes, but the mechanisms underlying this benefit …

Heart failure (HF) is associated with a reduced effective circulating volume that drives sodium
and water retention and extracellular volume expansion. We therefore hypothesized that …