Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and
mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. …

Coiled coils have a rich history in the field of protein design and engineering. Novel structures,
such as the first seven-helix coiled coil, continue to provide surprises and insights. Large-…

Current state-of-the-art approaches to computational protein design (CPD) aim to capture
the determinants of structure from physical principles. While this has led to many successful …

Despite advances in protein engineering, the de novo design of small proteins or peptides
that bind to a desired target remains a difficult task. Most computational methods search for …

The design of functional membrane proteins from first principles represents a grand
challenge in chemistry and structural biology. Here, we report the design of a membrane-spanning, …

There is a general need for the engineering of protein-like molecules that organize into
geometrically specific superstructures on molecular surfaces, directing further functionalization to …

Interaction specificity is a required feature of biological networks and a necessary characteristic
of protein or small-molecule reagents and therapeutics. The ability to alter or inhibit …

Three billion years of evolution has produced a tremendous diversity of protein molecules 1
, but the full potential of proteins is likely to be much greater. Accessing this potential has …

Here, we systematically decompose the known protein structural universe into its basic
elements, which we dub tertiary structural motifs (TERMs). A TERM is a compact backbone …

Because the space of folded protein structures is highly degenerate, with recurring
secondary and tertiary motifs, methods for representing protein structure in terms of collective …