Protein phosphorylation is estimated to affect 30% of the proteome and is a major regulatory
mechanism that controls many basic cellular processes 1 , 2 , 3 . Until recently, our …

We developed a new DNA microarray-based technology, called protein binding microarrays
(PBMs), that allows rapid, high-throughput characterization of the in vitro DNA binding–site …

Metagenomic sequencing increased our understanding of the role of the microbiome in
health and disease, yet it only provides a snapshot of a highly dynamic ecosystem. Here, we …

The living world is largely divided into autotrophs that convert CO 2 into biomass and
heterotrophs that consume organic compounds. In spite of widespread interest in renewable …

The economy of protein production is central to cell physiology, being intimately linked with
cell division rate and cell size. Attempts to model cellular physiology are limited by the …

Can a heterotrophic organism be evolved to synthesize biomass from CO 2 directly? So far,
non-native carbon fixation in which biomass precursors are synthesized solely from CO 2 …

Influenza virus encodes only 11 viral proteins but replicates in a broad range of avian and
mammalian species by exploiting host cell functions. Genome‐wide RNA interference (RNAi) …

To monitor severe acute respiratory syndrome (SARS) infection, a coronavirus protein
microarray that harbors proteins from SARS coronavirus (SARS-CoV) and five additional …

Genetically identical cells exposed to the same environment display variability in gene
expression (noise), with important consequences for the fidelity of cellular regulation and …

This is an important follow-up study to a previous paper in which the authors reconstituted
CO2 metabolism (autotrophy) in Escherichia coli. Here, the authors define a set of just three …