Acetylcholinesterase (AChE) has been found to be associated with the core of senile
plaques. We have shown that AChE interacts with the amyloid β-peptide (Aβ) and promotes …

Alzheimer’s disease (AD) is a neurodegenerative disease with progressive dementia
accompanied by three main structural changes in the brain: diffuse loss of neurons; intracellular …

Genome-wide linkage studies have defined a broad susceptibility region for late-onset
Alzheimer's disease on chromosome 12, which contains the Low-Density Lipoprotein Receptor-…

WNT signalling has been studied primarily in developing embryos, in which cells respond to
WNTs in a context-dependent manner through changes in survival and proliferation, cell …

Three-dimensional structures of acetylcholinesterase (AChE) reveal a narrow and deep active
site gorge with two sites of ligand binding, an acylation site at the base of the gorge, and a …

Background Increased expression of the cyclooxygenase-2 enzyme (COX2) is one of the
main characteristics of gastric cancer (GC), which is a leading cause of death in the world, …

Autism spectrum disorders (ASD) is a heterogeneous group of neurodevelopmental disorders
characterized by synaptic dysfunction and defects in dendritic spine morphology. In the …

A role for Wnt signal transduction in the development and maintenance of brain structures is
widely acknowledged. Recent studies have suggested that Wnt signaling may be essential …

Hundreds of genes have been associated with autism spectrum disorders (ASDs) and the
interaction of weak and de novo variants derive from distinct autistic phenotypes thus making …

Alzheimer’s disease (AD) is a progressive dementia paralleled by selective neuronal death,
which is probably caused by the cytotoxic effects of the amyloid-β peptide (Aβ). We have …