In-vitro and in-vivo antibacterial activity of BI 397, a new semi-synthetic glycopeptide antibiotic
G Candiani, M Abbondi, M Borgonovi… - Journal of …, 1999 - academic.oup.com
BI 397 (formerly AA-1) is a semisynthetic derivative of the teicoplanin-like glycopeptide
A40926. It was more active in vitro against staphylococci (including some teicoplanin-resistant …
A40926. It was more active in vitro against staphylococci (including some teicoplanin-resistant …
Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrug-resistant Gram-positive pathogens
D Jabés, C Brunati, GP Candiani, S Riva… - Antimicrobial Agents …, 2011 - Am Soc Microbiol
NAI-107 is a novel lantibiotic active against Gram-positive bacteria, including methicillin-resistant
Staphylococcus aureus (MRSA), glycopeptide-intermediate S. aureus (GISA), and …
Staphylococcus aureus (MRSA), glycopeptide-intermediate S. aureus (GISA), and …
[PDF][PDF] Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase
…, P Monciardini, C Mazzetti, P Guglierame, G Candiani… - Cell, 2017 - cell.com
Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the
discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits …
discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits …
A Novel Lantibiotic Acting on Bacterial Cell Wall Synthesis Produced by the Uncommon Actinomycete Planomonospora sp.
…, M Feroggio, I Ciciliato, E Corti, G Candiani… - Biochemistry, 2007 - ACS Publications
Important classes of antibiotics acting on bacterial cell wall biosynthesis, such as β-lactams
and glycopeptides, are used extensively in therapy and are now faced with a challenge …
and glycopeptides, are used extensively in therapy and are now faced with a challenge …
Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications
…, S Lam, J Trias, RJ White, G Candiani… - Bioorganic & medicinal …, 2003 - Elsevier
Thiazole peptide GE2270 A (1) possesses potent antimicrobial activity against many gram-positive
pathogens, including methicillin resistant Staphylococcus aureus (S. aureus, MRSA; …
pathogens, including methicillin resistant Staphylococcus aureus (S. aureus, MRSA; …
Efficacy of Dalbavancin against Methicillin-Resistant Staphylococcus aureus in the Rat Granuloma Pouch Infection Model
D Jabés, G Candiani, G Romanó… - Antimicrobial agents …, 2004 - Am Soc Microbiol
Infections due to methicillin-resistant Staphylococcus aureus (MRSA) are an important cause
of morbidity and mortality in hospital patients. Moreover, increased incidences of outpatient …
of morbidity and mortality in hospital patients. Moreover, increased incidences of outpatient …
Antimicrobial activity of MDL 63,246, a new semisynthetic glycopeptide antibiotic
BP Goldstein, G Candiani, TM Arain… - Antimicrobial agents …, 1995 - Am Soc Microbiol
MDL 63,246 is a semisynthetic derivative of the naturally occurring glycopeptide antibiotic
MDL 62,476 (A40926). It was more active in vitro against Staphylococcus aureus and …
MDL 62,476 (A40926). It was more active in vitro against Staphylococcus aureus and …
Synthesis and preliminary biological characterization of new semisynthetic derivatives of ramoplanin
…, G Romano, C Brunati, G Candiani… - Journal of medicinal …, 2007 - ACS Publications
Ramoplanin is a glycolipodepsipeptide antibiotic active against Gram-positive bacteria
including vancomycin-resistant enterococci. Ramoplanin inhibits bacterial cell wall biosynthesis …
including vancomycin-resistant enterococci. Ramoplanin inhibits bacterial cell wall biosynthesis …
Candida albicans strains deficient in CHS7, a key regulator of chitin synthase III, exhibit morphogenetic alterations and attenuated virulence
M Sanz, L Carrano, C Jimenez, G Candiani… - …, 2005 - microbiologyresearch.org
Chitin is a structural polysaccharide present in most fungal cell walls, whose synthesis depends
on a family of enzymic activities named chitin synthases (CSs). The specific role of each …
on a family of enzymic activities named chitin synthases (CSs). The specific role of each …
Synthesis and antibacterial activity of a series of basic amides of teicoplanin and deglucoteicoplanin with polyamines
…, J Kettenring, R Scotti, G Candiani… - Journal of medicinal …, 1992 - ACS Publications
Basic carboxamides of teicoplanin A2 (CTA) and its aglycon (TD) are prepared by condensation
of the 63-carboxyl function of these antibiotics with linear or branched polyamines. The …
of the 63-carboxyl function of these antibiotics with linear or branched polyamines. The …