The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a
collaborative network of researchers working together on a range of large-scale studies that …

This review examines the association of a subset of endothelial nitric oxide synthase gene (NOS3)
polymorphisms (Glu298Asp, intron 4, and -786T>C) with cardiovascular disease. The …

The mechanistic target of rapamycin signalling pathway serves as a ubiquitous regulator of
cell metabolism, growth, proliferation and survival. The main cellular activity of the …

Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …

By impairing both function and survival, the severe reduction in oxygen availability associated
with high-altitude environments is likely to act as an agent of natural selection. We used …

Background Carbamazepine causes various forms of hypersensitivity reactions, ranging from
maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been …

Abstract Analysis of 89 biallelic polymorphisms in 523 Turkish Y chromosomes revealed 52
distinct haplotypes with considerable haplogroup substructure, as exemplified by their …

Progressive functional decline in the epilepsies is largely unexplained. We formed the
ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, …

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …

Phenytoin and carbamazepine are effective and inexpensive anti-epileptic drugs (AEDs).
As with many AEDs, a broad range of doses is used, with the final “maintenance” dose …