Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome

G Friedman, O Levi-Galibov, E David, C Bornstein… - Nature Cancer, 2020 - nature.com
Tumors are supported by cancer-associated fibroblasts (CAFs). CAFs are heterogeneous
and carry out distinct cancer-associated functions. Understanding the full repertoire of CAFs …

[HTML][HTML] BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 …

…, A Ben-Shmuel, M Pevsner-Fischer, G Friedman… - Nature …, 2022 - nature.com
Tumors initiate by mutations in cancer cells, and progress through interactions of the cancer
cells with non-malignant cells of the tumor microenvironment. Major players in the tumor …

[BOOK][B] Agency, structure and international politics: From ontology to empirical inquiry

G Friedman, H Starr - 2002 - taylorfrancis.com
The concepts of agency and structure are of increasing and defining importance to international
relations and politics as fields of enquiry and knowledge. This is the first book to explore …

Cancer-associated fibroblasts promote aggressive gastric cancer phenotypes via heat shock factor 1–mediated secretion of extracellular vesicles

…, H Lavon, S Mayer, O Levi-Galibov, G Friedman… - Cancer research, 2021 - AACR
This study shows how HSF1 regulates a stromal transcriptional program associated with
aggressive gastric cancer and identifies multiple proteins within this program as candidates for …

[HTML][HTML] Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

…, Y Stein, LE Brown, W Zhang, G Friedman… - Nature …, 2020 - nature.com
In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer
(CAC) in patients with inflammatory bowel disease. While the causal and clinical links are …

[HTML][HTML] Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity

EG Kassa, E Zlotkin-Rivkin, G Friedman… - PLoS …, 2019 - journals.plos.org
Enteropathogenic E. coli (EPEC) is an extracellular diarrheagenic human pathogen which
infects the apical plasma membrane of the small intestinal enterocytes. EPEC utilizes a type III …

Retraction of enteropathogenic E. coli type IV pili promotes efficient host cell colonization, effector translocation and tight junction disruption

B Aroeti, G Friedman, E Zlotkin-Rivkin… - Gut …, 2012 - Taylor & Francis
Type IV pili (Tfp) play a primary role in mediating the adherence of pathogenic bacteria to
their hosts. The pilus filament can retract with an immense force. However, the role of this …

Commercial pacifism and protracted conflict: Models from the Palestinian-Israeli case

G Friedman - Journal of Conflict Resolution, 2005 - journals.sagepub.com
This study examines commercial pacifism and protracted conflict. It identifies constraints posed
by protracted conflict on both the opportunity of the rivals to engage in mutually beneficial …

Identifying the place of democratic norms in democratic peace

G Friedman - International Studies Review, 2008 - academic.oup.com
This essay contributes two arguments on the place of democratic norms in democratic peace.
First, the literature under-appreciates the inter-democracy moral constraint hypothesis: the …

Strategic deficiencies in national liberation struggles: The case of Fatah in the al-Aqsa Intifada

G Friedman - Journal of Strategic Studies, 2008 - Taylor & Francis
This study reports and explains a cluster of deviations from the basic rational criteria of
national liberation strategy exhibited by ‘inside’ West Bank Fatah leaders during the al-Aqsa …