Genome-wide CRISPR screens have transformed our ability to systematically interrogate
human gene function, but are currently limited to a subset of cellular phenotypes. We report a …

Although chromosome partitioning during mitosis is well studied, the molecular mechanisms
that allow proper segregation of cytoplasmic organelles in human cells are poorly …

Protein aggregates disrupt cellular homeostasis, causing toxicity linked to neurodegeneration.
Selective autophagic elimination of aggregates is critical to protein quality control, but …

Membrane-bound organelles are a wonderful evolutionary acquisition of the eukaryotic cell,
allowing the segregation of sometimes incompatible biochemical reactions into specific …

The VPS13 gene family consists of VPS13A–D in mammals. Although all four genes have
been linked to human diseases, their cellular functions are poorly understood, particularly …

The early pathogenesis and underlying molecular causes of motor neuron degeneration in
Parkinson’s Disease (PD) remains unresolved. In the model organism Drosophila …

During mitosis, cells undergo massive deformation and reorganization, impacting on all
cellular structures. Mitochondria, in particular, are highly dynamic organelles, which constantly …

Dynamic microtubule ends exert pulling and pushing forces on intracellular membranes and
organelles. However, the mechanical linkage of microtubule tips to their cargoes is poorly …

(Molecular Cell 80, 779–795. e1–e10; December 3, 2020) In the original published version
of this article, the graphs of the survival scores shown in Figures 6D and 6E were inaccurate. …

Certain cationic peptides interact with biological membranes. These often-complex interactions
can result in peptide targeting to the membrane, or in membrane permeation, rupture, …