User profiles for Gilad Yaakov

Gilad Yaakov

Weizmann Institute of Science
Verified email at mail.huji.ac.il
Cited by 1075

Measurement of histone replacement dynamics with genetically encoded exchange timers in yeast

G Yaakov, F Jonas, N Barkai - Nature Biotechnology, 2021 - nature.com
Histone exchange between histones carrying position-specific marks and histones bearing
general marks is important for gene regulation, but understanding of histone exchange …

Principles of cellular resource allocation revealed by condition-dependent proteome profiling

E Metzl-Raz, M Kafri, G Yaakov, I Soifer, Y Gurvich… - Elife, 2017 - elifesciences.org
10.7554/eLife.28034.001 Growing cells coordinate protein translation with metabolic rates.
Central to this coordination is ribosome production. Ribosomes drive cell growth, but …

DISARM is a widespread bacterial defence system with broad anti-phage activities

…, H Sberro, Z Mukamel, S Silverman, G Yaakov… - Nature …, 2018 - nature.com
The evolutionary pressure imposed by phage predation on bacteria and archaea has resulted
in the development of effective anti-phage defence mechanisms, including restriction–…

Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity

J Clotet, X Escoté, MÀ Adrover, G Yaakov, E Garí… - The EMBO …, 2006 - embopress.org
Control of cell cycle progression by stress‐activated protein kinases (SAPKs) is essential for
cell adaptation to extracellular stimuli. Exposure of yeast to osmostress leads to activation of …

Coordinated control of replication and transcription by a SAPK protects genomic integrity

A Duch, I Felipe-Abrio, S Barroso, G Yaakov… - Nature, 2013 - nature.com
Upon environmental changes or extracellular signals, cells are subjected to marked changes
in gene expression 1 , 2 . Dealing with high levels of transcription during replication is …

Gene transcription as a limiting factor in protein production and cell growth

E Metzl-Raz, M Kafri, G Yaakov… - G3: Genes, Genomes …, 2020 - academic.oup.com
Cell growth is driven by the synthesis of proteins, genes, and other cellular components.
Defining processes that limit biosynthesis rates is fundamental for understanding the …

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress

G Yaakov, A Duch, M García-Rubio… - Molecular biology of …, 2009 - Am Soc Cell Biol
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for
cell adaptation to extracellular stimuli. Exposure of yeast to osmostress activates the Hog1 …

Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress

G Yaakov, D Lerner, K Bentele, J Steinberger… - Nature ecology & …, 2017 - nature.com
Mutation rate balances the need to protect genome integrity with the advantage of
evolutionary innovations. Microorganisms increase their mutation rate when stressed, perhaps …

Nucleosome retention by histone chaperones and remodelers occludes pervasive DNA–protein binding

…, E Benuck, N Barkai, G Yaakov - Nucleic Acids …, 2023 - academic.oup.com
DNA packaging within chromatin depends on histone chaperones and remodelers that form
and position nucleosomes. Cells express multiple such chromatin regulators with …

[PDF][PDF] Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2ACdc55 regulation

G Yaakov, K Thorn, DO Morgan - Developmental cell, 2012 - cell.com
In anaphase, sister chromatids separate abruptly and are then segregated by the mitotic
spindle. The protease separase triggers sister separation by cleaving the Scc1/Mcd1 subunit of …