User profiles for Gilad Yaakov
Gilad YaakovWeizmann Institute of Science Verified email at mail.huji.ac.il Cited by 1075 |
Measurement of histone replacement dynamics with genetically encoded exchange timers in yeast
Histone exchange between histones carrying position-specific marks and histones bearing
general marks is important for gene regulation, but understanding of histone exchange …
general marks is important for gene regulation, but understanding of histone exchange …
Principles of cellular resource allocation revealed by condition-dependent proteome profiling
10.7554/eLife.28034.001 Growing cells coordinate protein translation with metabolic rates.
Central to this coordination is ribosome production. Ribosomes drive cell growth, but …
Central to this coordination is ribosome production. Ribosomes drive cell growth, but …
DISARM is a widespread bacterial defence system with broad anti-phage activities
…, H Sberro, Z Mukamel, S Silverman, G Yaakov… - Nature …, 2018 - nature.com
The evolutionary pressure imposed by phage predation on bacteria and archaea has resulted
in the development of effective anti-phage defence mechanisms, including restriction–…
in the development of effective anti-phage defence mechanisms, including restriction–…
Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity
Control of cell cycle progression by stress‐activated protein kinases (SAPKs) is essential for
cell adaptation to extracellular stimuli. Exposure of yeast to osmostress leads to activation of …
cell adaptation to extracellular stimuli. Exposure of yeast to osmostress leads to activation of …
Coordinated control of replication and transcription by a SAPK protects genomic integrity
Upon environmental changes or extracellular signals, cells are subjected to marked changes
in gene expression 1 , 2 . Dealing with high levels of transcription during replication is …
in gene expression 1 , 2 . Dealing with high levels of transcription during replication is …
Gene transcription as a limiting factor in protein production and cell growth
Cell growth is driven by the synthesis of proteins, genes, and other cellular components.
Defining processes that limit biosynthesis rates is fundamental for understanding the …
Defining processes that limit biosynthesis rates is fundamental for understanding the …
The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress
G Yaakov, A Duch, M García-Rubio… - Molecular biology of …, 2009 - Am Soc Cell Biol
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for
cell adaptation to extracellular stimuli. Exposure of yeast to osmostress activates the Hog1 …
cell adaptation to extracellular stimuli. Exposure of yeast to osmostress activates the Hog1 …
Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress
Mutation rate balances the need to protect genome integrity with the advantage of
evolutionary innovations. Microorganisms increase their mutation rate when stressed, perhaps …
evolutionary innovations. Microorganisms increase their mutation rate when stressed, perhaps …
Nucleosome retention by histone chaperones and remodelers occludes pervasive DNA–protein binding
DNA packaging within chromatin depends on histone chaperones and remodelers that form
and position nucleosomes. Cells express multiple such chromatin regulators with …
and position nucleosomes. Cells express multiple such chromatin regulators with …
[PDF][PDF] Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2ACdc55 regulation
In anaphase, sister chromatids separate abruptly and are then segregated by the mitotic
spindle. The protease separase triggers sister separation by cleaving the Scc1/Mcd1 subunit of …
spindle. The protease separase triggers sister separation by cleaving the Scc1/Mcd1 subunit of …