Abnormal protein aggregation within neurons is a key pathologic feature of Parkinson’s
disease (PD). The spread of brain protein aggregates is associated with clinical disease …

This study assessed morphological variation of the depth-generalist coral Montastraea
cavernosa across shallow and mesophotic coral ecosystems in the Gulf of Mexico (GOM) using …

Mutations in GBA (glucosylceramidase beta), which encodes the lysosomal enzyme
glucocerebrosidase (GCase), are the strongest genetic risk factor for the neurodegenerative …

This study assessed morphological variation in corallite structure of the depth-generalist
coral Montastraea cavernosa across shallow and mesophotic coral ecosystems in the Gulf of …

… Together with his postdoctoral fellows Matti Kaartinen, Claudia Berek, and Gillian Griffith,
Milstein made several fundamental discoveries in this system. They found that until 7 days after …

Studies on the development of the immune response suggest that the repertoire of expressed
antibody specificities is strongly influenced by antigen (reviewed in ref. 1). One way in …

Light and heavy chain mRNAs of 15 anti-oxazolone antibodies were sequenced directly using
synthetic primers. Hybridomas obtained 7 days after primary immunization show that they …

… In collaboration with Matti Kaartinen, Gillian Griffiths and Claudia Berek, we have been
conducting a study of the reponse to the hapten phenyl oxazolone (50,51). The essence of the …

… Most generallyused protocol for the derivation ofhybridomas [taken from Galfre and Milstein
(57)]… It remains to be seen to what extent other regulatory constraints are critical to the Gillian …

The heterogeneity of the antibody response presented a major problem to im-munochemists
wishing to study antibody structures. Such studies required large amounts of a single …