Hydroxyurea (HU) is a DNA replication inhibitor that negatively affects both the elongation
and initiation phases of replication and triggers the “intra-S phase checkpoint.” Previous work …

Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by
Dbf4-dependent kinase (DDK), composed of Cdc7 kinase and its activator, Dbf4. We report …

During DNA replication one or both strands transiently become single stranded: first at the
sites where initiation of DNA synthesis occurs (known as origins of replication) and …

Light management is a critical component of production for intensively housed animals. To
increase productivity, broiler chickens are often raised commercially in houses that are dimly …

Aging and longevity are complex traits influenced by genetic and environmental factors. To
identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred …

Temporal regulation of origin activation is widely thought to explain the pattern of early- and
late-replicating domains in the Saccharomyces cerevisiae genome. Recently, single-…

DNA replication in Saccharomyces cerevisiae proceeds according to a temporal program.
We have investigated the role of the telomere-binding Ku complex in specifying late …

Timely completion of genome replication is a prerequisite for mitosis, genome integrity, and
cell survival. A challenge to this timely completion comes from the need to replicate the …

Inherited and germ-line de novo copy number variants (CNVs) are increasingly found to be
correlated with human developmental and cancerous phenotypes. Several models for …

Chromosome replication in Saccharomyces cerevisiae is initiated from ~300 origins that are
regulated by DNA sequence and by the limited abundance of six trans-acting initiation …