BACKGROUND: Disease-modifying therapies for Alzheimer's disease (AD) would be most
effective during the preclinical stage (pathology present, cognition intact) before significant …

Identifying high-risk populations is an important component of disease prevention strategies.
One approach for identifying at-risk populations for Alzheimer's disease (AD) is examining …

Rationale: Survivors of hospitalization for community-acquired pneumonia (CAP) are at
increased risk of cardiovascular events, repeat infections, and death in the following months but …

Aggregation of amyloid-β (Aβ) as toxic oligomers and amyloid plaques within the brain
appears to be the pathogenic event that initiates Alzheimer's disease (AD) lesions. One …

Context Research on vascular depression has used 2 approaches to subtype late-life
depression, based on executive dysfunction or white matter hyperintensity severity. Objective To …

Objective To evaluate the cognitive reserve hypothesis by examining whether individuals of
greater educational attainment have better cognitive function than individuals with less …

Background: Optimal treatment of primary Merkel cell carcinoma (MCC) is unknown. High
local recurrence rates after excision alone compel some physicians to advocate postoperative …

According to the American Cancer Society, there are currently 2 million breast cancer (BC)
survivors in the USA and 20% of them cope with lymphedema (LE). The primary aim of this …

In vivo quantification of β-amyloid deposition using positron emission tomography is emerging
as an important procedure for the early diagnosis of the Alzheimer's disease and is likely …

Importance Synaptic loss is an early pathologic substrate of Alzheimer disease (AD).
Neurogranin is a postsynaptic neuronal protein that has demonstrated utility as a cerebrospinal …