Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of
a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that …

Homeostatic synaptic scaling adjusts a neuron's excitatory synaptic strengths up or down to
compensate for perturbations in activity. Little is known about the molecular pathway(s) …

Abstract Information is stored in neural circuits through long-lasting changes in synaptic
strengths 1 , 2 . Most studies of information storage have focused on mechanisms such as long-…

Activity has an important role in refining synaptic connectivity during development, in part
through 'Hebbian' mechanisms such as long-term potentiation and long-term depression. …

Cortical long-term plasticity depends on firing rate, spike timing, and cooperativity among
inputs, but how these factors interact during realistic patterns of activity is unknown. Here we …

During learning and development, neural circuitry is refined, in part, through changes in the
number and strength of synapses. Most studies of long-term changes in synaptic strength …

During learning and development, the level of synaptic input received by cortical neurons
may change dramatically. Given a limited range of possible firing rates, how do neurons …

We explore a synaptic plasticity model that incorporates recent findings that potentiation and
depression can be induced by precisely timed pairs of synaptic events and postsynaptic …

The positive-feedback nature of Hebbian plasticity can destabilize the properties of neuronal
networks. Recent work has demonstrated that this destabilizing influence is counteracted …

The mechanisms underlying experience-dependent plasticity and refinement of central
circuits are not yet fully understood. A non-Hebbian form of synaptic plasticity, which scales …