Background Diabetes mellitus (DM), a chronic disease characterized by hyperglycemia, is
an increasing global health problem which is associated with various chronic diseases such …

OBJECTIVES: Allograft vascular tissue is important in the repair of complex structural lesions
of the heart and great vessels, but induces a deleterious immune response that might …

OBJECTIVES: Cryopreserved valve allografts used in congenital cardiac surgery are
associated with a significant cellular and humoral immune response. This might be reduced by …

Sertoli cells have long since been recognized for their ability to suppress the immune system
and protect themselves as well as other cell types from harmful immune reaction. However, …

The International Xenotransplantation Association has updated its original “Consensus
Statement on Conditions for Undertaking Clinical Trials of Porcine Islet Products in Type 1 …

Objective We hypothesized that DA and L-DOPA derived from nutritional tyrosine and the
resultant observed postprandial plasma excursions of L-DOPA and DA might affect glucose …

Background. Recently, we have developed a simple and reliable method to efficiently isolate
large numbers of neonatal porcine islets (NPI). We and others have shown that NPI are …

Background: The immune mechanisms associated with the rejection of microencapsulated
neonatal porcine islets (NPI) are not clearly understood. Therefore, in this study we …

A variety of transient therapies directed against molecules involved in T-cell activation and
function result in long-term islet allograft survival. However, there are relatively few examples …

Scope Trans‐11 vaccenic acid (VA) is a fatty acid produced by ruminants entering the human
food supply through meat and dairy products, which appears not to have the health risks …