Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell
and progenitor cell populations 1 . One example is the deterioration of the regenerative …

The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs)
into mature OLGs are key to understanding myelination and remyelination. Signaling via …

The role of the neurovascular niche in CNS myelin regeneration is incompletely understood.
Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and …

Enhancing central nervous system (CNS) myelin regeneration is recognized as an important
strategy to ameliorate the devastating consequences of demyelinating diseases such as …

The increasing effectiveness of new disease‐modifying drugs that suppress disease activity
in multiple sclerosis has opened up opportunities for regenerative medicines that enhance …

The differentiation and maturation of oligodendrocyte precursor cells (OPCs) is essential for
myelination and remyelination in the CNS. The failure of OPCs to achieve terminal …

The microbiota is now recognized as a key influence on the host immune response in the
central nervous system (CNS). As such, there has been some progress toward therapies that …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that
leads to severe neurological deficits. Due to their immunomodulatory and neuroprotective …

New myelin sheaths can be restored to demyelinated axons in a spontaneous regenerative
process called remyelination. In general, new myelin sheaths are made by oligodendrocytes …

Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes
in the central nervous system (CNS). This evolutionary innovation, which first appears in …