Cells are constantly exposed to DNA damaging insults. To protect the organism, cells developed
a complex molecular response coordinated by P53, the master regulator of DNA repair, …

Extracellular vesicles, phospholipid bilayer-membrane vesicles of cellular origin, are emerging
as nanocarriers of biological information between cells. Extracellular vesicles transport …

Protein multimerization in physiological and pathological conditions constitutes an intrinsic
trait of proteins related to neurodegeneration. Recent evidence shows that TDP-43, a RNA-…

Simple Summary Extracellular vesicles are promising nanocarriers of active pharmaceutical
ingredients in precision medicine. However, to develop safe and effective extracellular …

Clinical progression of tauopathies may result from transcellular propagation of pathogenic
Tau seeds with the possible involvement of extracellular vesicles (EVs) as transport vectors. …

Clinical progression of tauopathies is reflected by the transcellular propagation of pathogenic
Tau seeds with the possible involvement of extracellular vesicles as transport vectors. …

On the verge of the ongoing coronavirus pandemic, in vitro data suggested that chloroquine,
and its analog hydroxychloroquine, may be useful in controlling SARS-CoV-2 infection. …

This thesis summarizes the main findings of the research project conducted from August
2016 until August 2020 at the Laboratory for Biomedical Neurosciences (LBN) of the Ente …

Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation
of membraneless compartments in cells. This realization has motivated major efforts to …