The transcription factor IRF4 regulates immunoglobulin class switch recombination and
plasma cell differentiation. Its differing concentrations appear to regulate mutually antagonistic …

The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has
recently gained interest, and different DDR inhibitors have been developed. Among them, the …

Germinal centers (GCs) are the sites where memory B cells and plasma cells producing high-affinity
antibodies are generated during T cell–dependent immune responses. The …

Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological potential,
intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML leukemia …

Interferon regulatory factor 4 (IRF4) is a member of the IRF family of transcription factors and
is expressed in most cell types of the immune system. Within the B‐cell lineage, IRF4 is …

Background Detecting somatic mutations in whole exome sequencing data of cancer
samples has become a popular approach for profiling cancer development, progression and …

The role of monocytes/macrophages in the development and progression of chronic lymphocytic
leukemia (CLL) is poorly understood. Transcriptomic analyses show that monocytes/…

Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it controls
the correct segregation of chromosomes during mitosis. Many studies have focused on …

Aneuploidy is a very rare and tissue‐specific event in normal conditions, occurring in a low
number of brain and liver cells. Its frequency increases in age‐related disorders and is one of …

Mouse models that recapitulate human malignancy are valuable tools for the elucidation of
the underlying pathogenetic mechanisms and for preclinical studies. Several genetically …