Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for
degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no …

The monoclonal antibody Ki‐67 reacts with a human nuclear cell proliferation‐associated
antigen that is expressed in all active parts of the cell cycle. Recently we have raised …

B cell–derived chronic lymphocytic leukemia (B-CLL) represents a common malignancy whose
cell derivation and pathogenesis are unknown. Recent studies have shown that >50% of …

Little is known of the molecular mechanisms whereby spermatogonia, mitotic germ cells of
the testis, self-renew and differentiate into sperm 1 , 2 . Here we show that Zfp145, encoding …

Structural alterations of the promoter region of the BCL-6 proto-oncogene represent the most
frequent genetic alteration associated with non-Hodgkin lymphoma, a malignancy often …

Mediastinal large B-cell lymphoma (MLBCL) is a recently identified subtype of diffuse large
B-cell lymphoma (DLBCL) that characteristically presents as localized tumors in young …

B cells producing high-affinity antibodies are destined to differentiate into memory B cells
and plasma cells, but the mechanisms leading to those differentiation pathways are mostly …

Enzymatic and non‐enzymatic treatments for antigen unmasking on formalin‐fixed, paraffin‐embedded,
dewaxed sections were optimized and compared by the use of a panel of …

Structural alterations of the 5′ noncoding region of the BCL-6 gene have been found in 40%
of diffuse large cell lymphoma (DLCL) and 5% to 10% of follicular lymphomas (FL), …

Germ line mutations in DNA mismatch repair genes including MLH1 cause hereditary
nonpolyposis colon cancer. To understand the role of MLH1 in normal growth and development, …