Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a
mystery, although recent work suggests that sleep, memory, and plasticity are linked. However…

Sleep appears to be a universally conserved phenomenon among the animal kingdom, but
whether this notable evolutionary conservation underlies a basic vital function is still an open …

Commissural axons grow along complex pathways toward, across, and beyond the midline
of the central nervous system. Taking commissural axons in the vertebrate spinal cord and …

Ligand-dependent downregulation of tyrosine kinase receptors is a critical step for modulating
their activity. Upon ligand binding, hepatocyte growth factor (HGF) receptor (Met) is …

Semaphorins are cell surface and soluble signals that control axonal guidance 1 , 2 .
Recently, semaphorin receptors (plexins) have been discovered and shown to be widely …

pySolo is a multiplatform software for analysis of sleep and locomotor activity in Drosophila
melanogaster. pySolo provides a user-friendly graphic interface and it has been developed …

Semaphorins are a large family of molecular cues implicated in neural development and in
a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a …

In the past decade, Drosophila has emerged as an ideal model organism for studying the
genetic components of sleep as well as its regulation and functions. In fruit flies, sleep can be …

Here, we present the use of ethoscopes, which are machines for high-throughput analysis
of behavior in Drosophila and other animals. Ethoscopes provide a software and hardware …

We have previously shown that the expression of a semaphorin, known as a repelling cue
in axon guidance, Sema3E, correlates with the ability to form lung metastasis in murine …