Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify
the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined …

Purpose Genetic counseling is now routinely offered to individuals at high risk of carrying a
BRCA1 or BRCA2 mutation. Risk prediction provided by the counselor requires reliable …

Researchers estimating causal effects are increasingly challenged with decisions on how to
best control for a potentially high-dimensional set of confounders. Typically, a single …

This book is intended to provide fundamental statistical concepts and tools relevant to the
analysis of genetic data arising from population-based association studies. Elementary …

There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we …

The elucidation of the human genome sequence has made it possible to identify genetic
alterations in cancers in unprecedented detail. To begin a systematic analysis of such …

Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor
genes. To catalog the genetic changes that occur during tumorigenesis, we isolated …

To assess changes since the mid-1970s, we reviewed 843 episodes of positive blood cultures
in 707 patients with septicemia. The five most common pathogens were Staphylococcus …

We show that the times separating the birth of benign, invasive, and metastatic tumor cells
can be determined by analysis of the mutations they have in common. When combined with …

Multiple myeloma is an incurable plasma cell malignancy with a complex and incompletely
understood molecular pathogenesis. Here we use whole-exome sequencing, copy-number …