Parkinson's disease (PD) is defined by the degeneration of nigral dopaminergic (DA)
neurons and can be caused by monogenic mutations of genes such as parkin. The lack of …

Background Next-generation sequencing is revealing genomic heterogeneity in localized
prostate cancer (CaP). Incomplete sampling of CaP multiclonality has limited the implications …

Purpose: During glutaminolysis, glutamine is catabolized to glutamate and incorporated into
citric acid cycle and lipogenesis. Serum glutamate levels were measured in patients with …

Current standard of care for muscle-invasive urothelial cell carcinoma (UCC) is surgery
along with perioperative platinum-based chemotherapy. UCC is sensitive to cisplatin-based …

African-American men have the highest incidence of and mortality from prostate cancer.
Whether a biological basis exists for this disparity remains unclear. Exome sequencing (n = 102) …

Hyperactivation of Akt is associated with oncogenic changes in the growth, survival, and
chemoresistance of cancer cells. The PI3K/phosphoinositide-dependent kinase (PDK) 1 …

Gene chip and proteomic analyses of tumors and stromal tissue has led to the identification
of dozens of candidate tumor and host components potentially involved in tumor-stromal …

The androgen receptor (AR) plays a critical role in prostate cancer (PCa) progression,
however, the molecular mechanisms by which the AR regulates cell proliferation in androgen-…

Lysine-specific demethylase 6A (KDM6A) and members of the Switch/Sucrose Non-Fermentable
(SWI/SNF) family are known to counteract the activity of Enhancer of Zeste Homolog 2 (…

Background Randomized trials have supported the use of cisplatin-based neoadjuvant
chemotherapy (NAC) in muscle-invasive bladder carcinoma (MIBC) owing to the survival …