Autophagy allows cell survival during starvation through the bulk degradation of proteins and
organelles by lysosomal enzymes. However, the mechanisms responsible for the induction …

Mitochondria are crucial organelles in the production of energy and in the control of signalling
cascades. A machinery of pro‐fusion and fission proteins regulates their morphology and …

Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …

Loss of muscle mass occurs in a variety of diseases, including cancer, chronic heart failure,
aquired immunodeficiency syndrome, diabetes, and renal failure, often aggravating …

The size of skeletal muscle cells is precisely regulated by intracellular signaling networks
that determine the balance between overall rates of protein synthesis and degradation. …

Cardiomyocyte proteostasis is mediated by the ubiquitin/proteasome system (UPS) and
autophagy/lysosome system and is fundamental for cardiac adaptation to both physiologic (eg, …

Aims Increased cardiac sympathetic neuron (SN) activity has been associated with pathologies
such as heart failure and hypertrophy, suggesting that cardiac innervation regulates …

Autophagy is a critical process in the regulation of muscle mass, function and integrity. The
molecular mechanisms regulating autophagy are complex and still partly understood. Here, …

Honeypots are active sensors deployed to obtain information about attacks. In their search
for vulnerabilities, attackers generate large volumes of logs, whose analysis is time …

Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates
signals from growth factors, energy and amino acids to activate protein synthesis and inhibit …