The liver is the largest solid organ in the body, yet it remains incompletely characterized.
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …

Microglia, the tissue-resident macrophages of the CNS, represent major targets for therapeutic
intervention in a wide variety of neurological disorders. Efficient reprogramming protocols …

The mononuclear phagocytic system consists of many cells, in particular macrophages,
scattered throughout the body. However, there is increasing evidence for the heterogeneity of …

Macrophages derive from multiple sources of hematopoietic progenitors. Most macrophages
require colony-stimulating factor 1 receptor (CSF1R), but some macrophages persist in the …

Per- and polyfluoroalkyl substances (PFASs) are used in a multitude of processes and
products, including nonstick coatings, food wrappers, and fire-fighting foams. These chemicals …

In vertebrates, the ontogeny of microglia, the resident macrophages of the central nervous
system, initiates early during development from primitive macrophages. Although murine …

Perineuronal nets (PNNs) are extracellular matrix structures that form around some types of
neurons at the end of critical periods, limiting neuronal plasticity. In the adult brain, PNNs …

Normal development of the immune system is essential for overall health and disease
resistance. Bony fish, such as the zebrafish (Danio rerio), possess all the major immune cell …

Recent studies have highlighted the heterogeneity of the immune cell compartment within
the steady-state murine and human CNS. However it is not known whether this diversity is …

Microglia are tissue-resident macrophages in the central nervous system. They represent a
distinct population of mononuclear phagocytes that serve multiple functions in brain …