Putative “stem” cells (SCs) are increasingly envisioned and postulated in discussions and
experimental work dealing with the origin and differentiation of postnatal mesodermal tissues. …

Duchenne muscular dystrophy (DMD) is a common X-linked disease characterized by
widespread muscle damage that invariably leads to paralysis and death. There is currently no …

Duchenne muscular dystrophy remains an untreatable genetic disease that severely limits
motility and life expectancy in affected children. The only animal model specifically …

Growth and repair of skeletal muscle are normally mediated by the satellite cells that
surround muscle fibers. In regenerating muscle, however, the number of myogenic precursors …

Cardiac myocytes have been traditionally regarded as terminally differentiated cells that adapt
to increased work and compensate for disease exclusively through hypertrophy. However…

Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy
is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, …

Cells derived from blood vessels of human skeletal muscle can regenerate skeletal muscle,
similarly to embryonic mesoangioblasts. However, adult cells do not express endothelial …

We analyzed Pax-3 (splotch)Myf-5 (targeted with nlacZ), and splotch/Myf-5 homozygous mutant
mice to investigate the roles that these genes play in programming skeletal myogenesis. …

Preclinical or clinical trials for muscular dystrophies have met with modest success, mainly
because of inefficient delivery of viral vectors or donor cells to dystrophic muscles. We report …

Satellite cells are dormant progenitors located at the periphery of skeletal myofibers that can
be triggered to proliferate for both self-renewal and differentiation into myogenic cells. In …