User profiles for Giulio Genovese
Giulio GenoveseStanley Canter at Broad Institute Verified email at broadinstitute.org Cited by 42248 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
…, M Fromer, A Frustaci, A Gadelha, G Genovese… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …
[HTML][HTML] Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
G Genovese, AK Kähler, RE Handsaker… - … England Journal of …, 2014 - Mass Medical Soc
Background Cancers arise from multiple acquired mutations, which presumably occur over
many years. Early stages in cancer development might be present years before cancers …
many years. Early stages in cancer development might be present years before cancers …
Schizophrenia risk from complex variation of complement component 4
…, J Presumey, M Baum, V Van Doren, G Genovese… - Nature, 2016 - nature.com
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms.
Schizophrenia’s strongest genetic association at a population level involves variation in the major …
Schizophrenia’s strongest genetic association at a population level involves variation in the major …
Association of trypanolytic ApoL1 variants with kidney disease in African Americans
G Genovese, DJ Friedman, MD Ross, L Lecordier… - Science, 2010 - science.org
African Americans have higher rates of kidney disease than European Americans. Here, we
show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and …
show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and …
A polygenic burden of rare disruptive mutations in schizophrenia
Schizophrenia is a common disease with a complex aetiology, probably involving multiple
and heterogeneous genetic factors. Here, by analysing the exome sequences of 2,536 …
and heterogeneous genetic factors. Here, by analysing the exome sequences of 2,536 …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
Rare coding variants in ten genes confer substantial risk for schizophrenia
…, D Gage, SA Gagliano Taliun, A Ganna, G Genovese… - Nature, 2022 - nature.com
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
Chromosomal instability drives metastasis through a cytosolic DNA response
…, K Chadalavada, VK Rajasekhar, G Genovese… - Nature, 2018 - nature.com
Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome
segregation during mitosis. Although chromosomal instability is a major driver of tumour …
segregation during mitosis. Although chromosomal instability is a major driver of tumour …
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …
APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy
…, K Sampath, RC Johnson, G Genovese… - Journal of the …, 2011 - journals.lww.com
Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney
disease in African Americans, but whether APOL1-associated glomerular disease has a distinct …
disease in African Americans, but whether APOL1-associated glomerular disease has a distinct …