The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of
signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified …

Successful infection by enteric bacterial pathogens depends on the ability of the bacteria to
colonize the gut, replicate in host tissues and disseminate to other hosts. Pathogens such as …

For the characterization of protein sequences and post‐translational modifications by MS,
the ‘top‐down’ proteomics approach utilizes molecular and fragment ion mass data obtained …

10.7554/eLife.20444.001 Influenza virus infections have a significant impact on global
human health. Individuals with suppressed immunity, or suffering from chronic inflammatory …

Exosomes are extracellular vesicles secreted by cells that have an important biological
function in intercellular communication by transferring biologically active proteins, lipids, and …

Selecting a sample preparation strategy for mass spectrometry-based proteomics is critical
to the success of quantitative workflows. Here we present a universal, solid-phase protein …

Phytochelatin synthase (PCS) is a major determinant of heavy metal tolerance in plants and
other organisms. No structural information on this enzyme is as yet available. It is generally …

Toxoplasma gondii infects approximately 30% of the world’s population, causing disease
primarily during pregnancy and in individuals with weakened immune systems. Toxoplasma …

Purpose For the vast majority of ovarian cancer patients, optimal surgical debulking remains
a key prognostic factor associated with improved survival. A standardized, biomarker‐based …

NSP protein family members associate with p130Cas, a focal adhesion adapter protein best
known as a Src substrate that integrates adhesion-related signaling. Over-expression of …