User profiles for Giuseppe Leuzzi
 | Giuseppe LeuzziColumbia University Medical Center Verified email at cumc.columbia.edu Cited by 1107 |
[PDF][PDF] Restoration of replication fork stability in BRCA1-and BRCA2-deficient cells by inactivation of SNF2-family fork remodelers
To ensure the completion of DNA replication and maintenance of genome integrity, DNA
repair factors protect stalled replication forks upon replication stress. Previous studies have …
repair factors protect stalled replication forks upon replication stress. Previous studies have …
[PDF][PDF] Functional interrogation of DNA damage response variants with base editing screens
Mutations in DNA damage response (DDR) genes endanger genome integrity and predispose
to cancer and genetic disorders. Here, using CRISPR-dependent cytosine base editing …
to cancer and genetic disorders. Here, using CRISPR-dependent cytosine base editing …
[PDF][PDF] REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
BRCA1/2 mutant tumor cells display an elevated mutation burden, the etiology of which
remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous …
remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous …
The DNA damage response and inflammation in cancer
Accumulating preclinical and clinical evidence indicates that DDR is intimately connected to
the emission of immunomodulatory signals by normal and malignant cells, as part of a cell-…
the emission of immunomodulatory signals by normal and malignant cells, as part of a cell-…
[HTML][HTML] Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant
Precise editing of genomic DNA can be achieved upon repair of CRISPR-induced DNA
double-stranded breaks (DSBs) by homology-directed repair (HDR). However, the efficiency of …
double-stranded breaks (DSBs) by homology-directed repair (HDR). However, the efficiency of …
[PDF][PDF] Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
How cancer-associated chromatin abnormalities shape tumor-immune interaction remains
incompletely understood. Recent studies have linked DNA hypomethylation and de-…
incompletely understood. Recent studies have linked DNA hypomethylation and de-…
WRNIP 1 protects stalled forks from degradation and promotes fork restart after replication stress
G Leuzzi, V Marabitti, P Pichierri, A Franchitto - The EMBO journal, 2016 - embopress.org
Accurate handling of stalled replication forks is crucial for the maintenance of genome
stability. RAD 51 defends stalled replication forks from nucleolytic attack, which otherwise can …
stability. RAD 51 defends stalled replication forks from nucleolytic attack, which otherwise can …
[PDF][PDF] The BRCT domains of the BRCA1 and BARD1 tumor suppressors differentially regulate homology-directed repair and stalled fork protection
…, M Horiguchi, F Wu-Baer, A Taglialatela, G Leuzzi… - Molecular cell, 2018 - cell.com
The BRCA1 tumor suppressor preserves genome integrity through both homology-directed
repair (HDR) and stalled fork protection (SFP). In vivo, BRCA1 exists as a heterodimer with …
repair (HDR) and stalled fork protection (SFP). In vivo, BRCA1 exists as a heterodimer with …
[HTML][HTML] MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
Homologous recombination (HR) mediates the error-free repair of DNA double-strand
breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold …
breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold …
[HTML][HTML] Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia
Human NK cell deficiency (NKD) is a primary immunodeficiency in which the main clinically
relevant immunological defect involves missing or dysfunctional NK cells. Here, we describe …
relevant immunological defect involves missing or dysfunctional NK cells. Here, we describe …