SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase and a nuclease that
restricts HIV-1 in noncycling cells. Germ-line mutations in SAMHD1 have been described in …

Quantitative systems pharmacology (QSP) models aim to describe mechanistically the
pathophysiology of disease and predict the effects of therapies on that disease. For most drug …

Weaning from mechanical ventilation in the intensive care unit (ICU) is a complex clinical
problem and relevant for future organ engineering. Prolonged mechanical ventilation (MV) …

Gaussian process regression (GPR) provides a means to generate flexible personalized
models of time series of patient vital signs. These models can perform useful clinical inference …

The step-down unit (SDU) is a high-acuity hospital environment, to which patients may be
sent after discharge from the intensive care unit (ICU). About 1- in-7 patients will deteriorate in …

Patient deterioration in the hospital ward is typically preceded by several hours of deranged
physiology, as measured by the patient's vital signs. Estimation of the expected trajectory of …

Patients in a hospital step-down unit require a level of care that is between that of the intensive
care unit (ICU) and that of the general ward. While many patients remain physiologically …

Statistical models for clinical risk prediction are often derived using data from primary care
databases; however, they are frequently used outside of clinical settings. The use of prediction …

Robust continuous monitoring of patient vital signs (VS) is limited by artefactual data yielding
measurements that are not representative of the patient's physiology. These artefacts are …

… GLEN WRIGHT COLOPY received the BS degrees in mathematics and economics from
the College of William and Mary, the M.Sc. degree in applied statistics from the University of …