Clues to the pathogenesis of familial colorectal cancer
…, SM Powell, J Jen, SR Hamilton, GM Petersen… - Science, 1993 - science.org
A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in
some families. Molecular features of "familial" cancers were compared with those of sporadic …
some families. Molecular features of "familial" cancers were compared with those of sporadic …
Genomic analyses identify molecular subtypes of pancreatic cancer
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…
[HTML][HTML] Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
…, J Weissenbach, JP Mecklin, H Järvinen, GM Petersen… - Cell, 1993 - cell.com
Recent studies have shown that a locus responsible for hereditary nonpolyposis colorectal
cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain …
cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain …
Mutation of a mutL Homolog in Hereditary Colon Cancer
…, MD Adams, JC Venter, SR Hamilton, GM Petersen… - Science, 1994 - science.org
Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in
a mutS-related mismatch repair gene. A search of a large database of expressed sequence …
a mutS-related mismatch repair gene. A search of a large database of expressed sequence …
Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer
…, JC Venter, MG Dunlop, SR Hamilton, GM Petersen… - Nature, 1994 - nature.com
HEREDITARY nonpolyposis colorectal cancer (HNPCC) is one of man's commonest
hereditary diseases 1 . Several studies have implicated a defect in DNA mismatch repair in the …
hereditary diseases 1 . Several studies have implicated a defect in DNA mismatch repair in the …
Very high risk of cancer in familial Peutz–Jeghers syndrome
…, GM Petersen, SV Booker, M Cruz–Correa… - Gastroenterology, 2000 - Elsevier
Background & Aims: The Peutz–Jeghers syndrome (PJS) is an autosomal dominant
polyposis disorder with increased risk of multiple cancers, but literature estimates of risk vary. …
polyposis disorder with increased risk of multiple cancers, but literature estimates of risk vary. …
[HTML][HTML] The molecular basis of Turcot's syndrome
…, F Taqi, SV Booker, GM Petersen… - … England Journal of …, 1995 - Mass Medical Soc
Background Turcot's syndrome is characterized clinically by the concurrence of a primary
brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the …
brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the …
Genetic mapping of a locus predisposing to human colorectal cancer
Genetic linkage analysis was used to determine whether a specific chromosomal locus
could be implicated in families with a history of early onset cancer but with no other unique …
could be implicated in families with a history of early onset cancer but with no other unique …
[PDF][PDF] Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors
…, DJ Sargent, C Walsh-Vockley, GM Petersen… - Journal of clinical …, 2002 - seom.org
Purpose: To compare microsatellite instability (MSI) testing with immunohistochemical (IHC)
detection of hMLH1 and hMSH2 in colorectal cancer. Patients and Methods: Colorectal …
detection of hMLH1 and hMSH2 in colorectal cancer. Patients and Methods: Colorectal …
[HTML][HTML] Molecular diagnosis of familial adenomatous polyposis
SM Powell, GM Petersen, AJ Krush… - … England Journal of …, 1993 - Mass Medical Soc
Background Familial adenomatous polyposis is an inherited disease characterized by multiple
colorectal tumors. The diagnosis has classically been based on the detection of multiple …
colorectal tumors. The diagnosis has classically been based on the detection of multiple …