[HTML][HTML] ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING
K Aden, F Tran, GO Ito, R Sheibani-Tezerji… - Journal of Experimental …, 2018 - rupress.org
A coding variant of the inflammatory bowel disease (IBD) risk gene ATG16L1 has been
associated with defective autophagy and deregulation of endoplasmic reticulum (ER) function. IL-…
associated with defective autophagy and deregulation of endoplasmic reticulum (ER) function. IL-…
[HTML][HTML] Activating transcription factor 6 mediates inflammatory signals in intestinal epithelial cells upon endoplasmic reticulum stress
Background & Aims Excess and unresolved endoplasmic reticulum (ER) stress in intestinal
epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 (ATF6…
epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 (ATF6…
[HTML][HTML] Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties
Background Intestinal stem cells (ISCs) play indispensable roles in the maintenance of
homeostasis, and also in the regeneration of the damaged intestinal epithelia. However, whether …
homeostasis, and also in the regeneration of the damaged intestinal epithelia. However, whether …
[PDF][PDF] Contribution of ATOH1+ cells to the homeostasis, repair, and tumorigenesis of the colonic epithelium
…, A Kawamoto, S Anzai, R Kuno, S Nagata, G Ito… - Stem cell reports, 2018 - cell.com
ATOH1 is a master transcription factor for the secretory lineage differentiation of intestinal
epithelial cells (IECs). However, the comprehensive contribution of ATOH1 + secretory lineage …
epithelial cells (IECs). However, the comprehensive contribution of ATOH1 + secretory lineage …
[HTML][HTML] Epithelial RNase H2 maintains genome integrity and prevents intestinal tumorigenesis in mice
Background & Aims RNase H2 is a holoenzyme, composed of 3 subunits (ribonuclease H2
subunits A, B, and C), that cleaves RNA:DNA hybrids and removes mis-incorporated …
subunits A, B, and C), that cleaves RNA:DNA hybrids and removes mis-incorporated …
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease
…, AH Skogholt, S Chen, PR Strege, G Ito… - Gut, 2021 - gut.bmj.com
Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the
population but its aetiology, including suspected genetic predisposition, is poorly understood. …
population but its aetiology, including suspected genetic predisposition, is poorly understood. …
[HTML][HTML] DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon
…, ST Stengel, P Arnold, D Ellinghaus, G Ito… - Nature …, 2022 - nature.com
Genetic variants in the DNA methyltransferase 3 A (DNMT3A) locus have been associated
with inflammatory bowel disease (IBD). DNMT3A is part of the epigenetic machinery …
with inflammatory bowel disease (IBD). DNMT3A is part of the epigenetic machinery …
[HTML][HTML] Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells
G Ito, R Okamoto, T Murano, H Shimizu, S Fujii… - PloS one, 2013 - journals.plos.org
Intestinal epithelial cells (IECs) regulate the absorption and secretion of anions, such as
HCO3 - or Cl - . Bestrophin genes represent a newly identified group of calcium-activated Cl - …
HCO3 - or Cl - . Bestrophin genes represent a newly identified group of calcium-activated Cl - …
Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells
T Murano, R Okamoto, G Ito, T Nakata, S Hibiya… - Biochemical and …, 2014 - Elsevier
Notch signaling plays an essential role in the proliferation and differentiation of intestinal
epithelial cells (IECs). We have previously shown that Notch signaling is up-regulated in the …
epithelial cells (IECs). We have previously shown that Notch signaling is up-regulated in the …
[HTML][HTML] Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation
…, Y Okamoto-Uchida, S Kofuji, H Shimizu, G Ito… - Inflammation and …, 2022 - Springer
… into another 50-ml conical tube by passing through a 70-μm pore size mesh filter. The total
volume was adjusted to 10 mL with 0.1% v/v BSA/PBS into a … Matrigel organoids into collagen …
volume was adjusted to 10 mL with 0.1% v/v BSA/PBS into a … Matrigel organoids into collagen …