Lysosome fission: planning for an exit
GT Saffi, RJ Botelho - Trends in cell biology, 2019 - cell.com
Lysosomes are acidic and degradative organelles that receive and digest a plethora of
molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The …
molecular and particulate cargo delivered by endocytosis, autophagy, and phagocytosis. The …
Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence
CH Choy, G Saffi, MA Gray, C Wallace… - Journal of cell …, 2018 - journals.biologists.com
Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy.
They also play an important role in sensing and instructing cells on their metabolic state. The …
They also play an important role in sensing and instructing cells on their metabolic state. The …
[HTML][HTML] Characterization of a PIP Binding Site in the N-Terminal Domain of V-ATPase a4 and Its Role in Plasma Membrane Association
A Chu, Y Yao, GT Saffi, JH Chung, RJ Botelho… - International Journal of …, 2023 - mdpi.com
Vacuolar ATPases (V-ATPases) are multi-subunit ATP-dependent proton pumps necessary
for cellular functions, including pH regulation and membrane fusion. The evidence suggests …
for cellular functions, including pH regulation and membrane fusion. The evidence suggests …
[HTML][HTML] Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition
Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo
repeated fusion-fission cycles with themselves, endosomes, phagosomes, and …
repeated fusion-fission cycles with themselves, endosomes, phagosomes, and …
Amyloid-β inhibits PDGFβ receptor activation and prevents PDGF-BB-induced neuroprotection
H Liu, GT Saffi, MS Vasefi, Y Choi… - Current Alzheimer …, 2018 - ingentaconnect.com
Background: PDGFβ receptors and their ligand, PDGF-BB, are upregulated in vivo after
neuronal insults such as ischemia. When applied exogenously, PDGF-BB is neuroprotective …
neuronal insults such as ischemia. When applied exogenously, PDGF-BB is neuroprotective …
[HTML][HTML] Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI (3) P-mediated lysosome dynamics through VPS34 activity
GT Saffi, CA Wang, EM Mangialardi, J Vacher… - Journal of Biological …, 2022 - ASBMB
Lysosome membranes contain diverse phosphoinositide (PtdIns) lipids that coordinate
lysosome function and dynamics. The PtdIns repertoire on lysosomes is tightly regulated by the …
lysosome function and dynamics. The PtdIns repertoire on lysosomes is tightly regulated by the …
[PDF][PDF] INPP4B promotes leukemia by restricting leukemic stem cell differentiation through regulation of lysosomal functions
…, DKC Lee, I Dzneladze, R He, MM Gabra, GT Saffi… - BioRxiv, 2021 - academia.edu
Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow
characterized by dysregulated proliferation of immature myeloid cells and dismal survival …
characterized by dysregulated proliferation of immature myeloid cells and dismal survival …
[HTML][HTML] The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in …
K Chintaluri, BD Goulden, C Celmenza, G Saffi… - Plos one, 2018 - journals.plos.org
Phosphoinositide (PtdInsP) lipids recruit effector proteins to membranes to mediate a variety
of functions including signal transduction and membrane trafficking. Each PtdInsP binds to a …
of functions including signal transduction and membrane trafficking. Each PtdInsP binds to a …
[PDF][PDF] Reactive oxygen species rescue lysosome coalescence during PIKfyve inhibition
GT Saffi, E Tang, A Fountain, RJ Botelho - BioRxiv, 2019 - scholar.archive.org
Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo
repeated fusion-fission cycles with themselves and other organelles like endosomes, …
repeated fusion-fission cycles with themselves and other organelles like endosomes, …
Correction: The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in …
K Chintaluri, BD Goulden, C Clemenza, G Saffi… - Plos one, 2018 - journals.plos.org
The third author’s name is spelled incorrectly. The correct name is: Camilyn Clemenza. The
correct citation is: Chintaluri K, Goulden BD, Clemenza C, Saffi G, Miraglia E, Hammond GRV…
correct citation is: Chintaluri K, Goulden BD, Clemenza C, Saffi G, Miraglia E, Hammond GRV…