We conducted a double-blinded phase I clinical trial to establish whether nicotinamide
adenine dinucleotide (NAD) replenishment therapy, via oral intake of nicotinamide riboside (NR), …

Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice,
and mtDNA damage accumulates in the human brain with aging and neurodegenerative …

Background Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder
of largely unknown etiology. PD is strongly associated with mitochondrial respiratory …

… Author links open overlay panel Gonzalo S. Nido a b , Christian Dölle a b , Irene Flønes a
b , Helen A. Tuppen c , Guido Alves d e , Ole-Bjørn Tysnes a b , Kristoffer Haugarvoll a b , …

Background: Mitochondrial dysfunction plays a key role in PD, but the underlying molecular
mechanisms remain unresolved. We hypothesized that the disruption of mitochondrial …

The etiology of Parkinson’s disease is largely unknown. Genome-wide transcriptomic
studies in bulk brain tissue have identified several molecular signatures associated with the …

The molecular clock hypothesis, stating that protein sequences diverge in evolution by
accumulating amino acid substitutions at an almost constant rate, played a major role in the …

While most research suggests mitochondrial DNA (mtDNA) harbors low or no methylation, a
few studies claim to report evidence of high-level methylation in the mtDNA. The reasons …

Background Variation in cell composition can dramatically impact analyses in bulk tissue
samples. A commonly employed approach to mitigate this issue is to adjust statistical models …

Replenishing nicotinamide adenine dinucleotide (NAD) via supplementation of nicotinamide
riboside (NR) has been shown to confer neuroprotective effects in models of aging and …