Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers,
but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor …

Tumor molecular profiling is a fundamental component of precision oncology, enabling the
identification of genomic alterations in genes and pathways that can be targeted …

Purpose With prospective clinical sequencing of tumors emerging as a mainstay in cancer
care, an urgent need exists for a clinical support tool that distills the clinical implications …

We sought to define whether there are intrinsic molecular subtypes of high-grade bladder
cancer. Consensus clustering performed on gene expression data from a meta-dataset of high-…

Cancer drugs often induce dramatic responses in a small minority of patients. We used
whole-genome sequencing to investigate the genetic basis of a durable remission of metastatic …

Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively)
are found in a wide range of cancers. Preclinical modelling suggests that a subset of these …

Cisplatin-based chemotherapy is the standard of care for patients with muscle-invasive
urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based …

Broad and deep tumour genome sequencing has shed new light on tumour heterogeneity
and provided important insights into the evolution of metastases arising from different clones 1 …

Ploidy abnormalities are a hallmark of cancer, but their impact on the evolution and outcomes
of cancers is unknown. Here, we identified whole-genome doubling (WGD) in the tumors …

Purpose Alterations in DNA damage response and repair (DDR) genes are associated with
increased mutation load and improved clinical outcomes in platinum-treated metastatic …