Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches.
Given that the elderly population is dramatically increasing and that aging is the greatest risk …

We tested the theory that reactive oxygen species cause aging. We augmented the natural
antioxidant systems ofCaenorhabditis elegans with small synthetic superoxide dismutase/…

We have discovered that three longevity mutants of the nematode Caenorhabditis elegans
also exhibit increased intrinsic thermotolerance (Itt) as young adults. Mutation of the age-1 …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific …

Aging constitutes the key risk factor for age‐related diseases such as cancer and cardiovascular
and neurodegenerative disorders. Human longevity and healthy aging are complex …

Protein synthesis is a regulated cellular process that links nutrients in the environment to
organismal growth and development. Here we examine the role of genes that regulate mRNA …

Senescence is a cellular program that irreversibly arrests the proliferation of damaged cells
and induces the secretion of the inflammatory mediators IL-6 and IL-8 which are part of a …

Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in mice…

Genetic studies indicate that protein homeostasis is a major contributor to metazoan
longevity 1 . Collapse of protein homeostasis results in protein misfolding cascades and the …

Insulin‐like signalling is a key determinate of lifespan in diverse species including mammals
but the mechanism by which this pathway influences the rate of aging is unknown. In the …